Utilizing the folate receptor for active targeting of cancer nanotherapeutics

Nano Reviews & Experiments

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Title Utilizing the folate receptor for active targeting of cancer nanotherapeutics
 
Creator Zwicke, Grant L.; University of Illinois at Chicago
Mansoori, G. Ali; University of Illinois at Chicago
Jeffery, Constance J.; University of Illinois at Chicago
 
Subject cancer; conjugates; doxorubicin; folate; folic acid; folate receptor; gold; nanoaggregates;99mTc--EC20; nanotechnology; PET
 
Description The development of specialized nanoparticles for use in the detection and treatment of cancer is increasing. Methods are being proposed and tested that could target treatments more directly to cancer cells, which could lead to higher efficacy and reduced toxicity, possibly even eliminating the adverse effects of damage to the immune system and the loss of quick replicating cells. In this mini-review we focus on recent studies that employ folate nanoconjugates to target the folate receptor. Folate receptors are highly overexpressed on the surface of many tumor types. This expression can be exploited to target imaging molecules and therapeutic compounds directly to cancerous tissues.Keywords: cancer; conjugates; doxorubicin; folate; folic acid; folate receptor; gold; nanoaggregates; 99mTc-EC20; nanotechnology(Published: 7 December 2012)Citation: Nano Reviews 2012, 3: 18496 - http://dx.doi.org/10.3402/nano.v3i0.18496
 
Publisher Co-Action Publishing
 
Contributor
 
Date 2012-12-07
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
text/html
application/epub+zip
text/xml
 
Identifier http://www.nanoreviewsexperiments.net/index.php/nano/article/view/18496
10.3402/nr.v3i0.18496
 
Source Nano Reviews & Experiments; Vol 3 (2012) incl Supplements
2002-2727
 
Language eng
 
Relation http://www.nanoreviewsexperiments.net/index.php/nano/article/view/18496/25002
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/18496/25003
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/18496/25005
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/18496/25006
 

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