Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II

Nano Reviews & Experiments

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Field Value
 
Title Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II
 
Creator Zhang, Mengmeng; University of Texas at Austin
Gill, Gordon N.; University of California San Diego
Zhang, Yan; University of Texas at Austin
 
Subject C-terminal domain; RNA polymerase II; transcription regulation; phosphorylation; CTD code; WW domain; CID domain; SRI domain; FF domain; histone code; epigenetic regulation.
 
Description In eukaryotic cells, the transcription of genes is accurately orchestrated both spatially and temporally by the C-terminal domain of RNA polymerase II (CTD). The CTD provides a dynamic platform to recruit different regulators of the transcription apparatus. Different posttranslational modifications are precisely applied to specific sites of the CTD to coordinate transcription process. Regulators of the RNA polymerase II must identify specific sites in the CTD for cellular survival, metabolism, and development. Even though the CTD is disordered in the eukaryotic RNA polymerase II crystal structures due to its intrinsic flexibility, recent advances in the complex structural analysis of the CTD with its binding partners provide essential clues for understanding how selectivity is achieved for individual site recognition. The recent discoveries of the interactions between the CTD and histone modification enzymes disclose an important role of the CTD in epigenetic control of the eukaryotic gene expression. The intersection of the CTD code with the histone code discloses an intriguing yet complicated network for eukaryotic transcriptional regulation. Keywords: C-terminal domain; RNA polymerase II; transcription regulation; phosphorylation; CTD code; WW domain; CID domain; SRI domain; FF domain; histone code; epigenetic regulation (Published: 30 August 2010) Citation: Nano Reviews 2010, 1: 5502 - DOI: 10.3402/nano.v1i0.5502
 
Publisher Co-Action Publishing
 
Contributor
 
Date 2010-08-30
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
text/html
text/xml
 
Identifier http://www.nanoreviewsexperiments.net/index.php/nano/article/view/5502
10.3402/nr.v1i0.5502
 
Source Nano Reviews & Experiments; Vol 1 (2010) incl Supplements
2002-2727
 
Language eng
 
Relation http://www.nanoreviewsexperiments.net/index.php/nano/article/view/5502/5945
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/5502/5947
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/5502/5946
 

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