A concise review of carbon nanotube’s toxicology

Nano Reviews & Experiments

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Field Value
 
Title A concise review of carbon nanotube’s toxicology
 
Creator Madani, Seyed Yazdan
Mandel, Abraham
Seifalian, Alexander M.; University of College London
 
Subject carbon nanotubes; toxicology; distribution; administration
 
Description Carbon nanotubes can be either single-walled or multiwalled, each of which is known to have a different electron arrangement and as a result have different properties. However, the shared unique properties of both types of carbon nanotubes (CNT) allow for their potential use in various biomedical devices and therapies. Some of the most common properties of these materials include the ability to absorb near-infra-red light and generate heat, the ability to deliver drugs in a cellular environment, their light weight, and chemical stability. These properties have encouraged scientists to further investigate CNTs as a tool for thermal treatment of cancer and drug delivery agents. Various promising data have so far been obtained about the usage of CNTs for cancer treatment; however, toxicity of pure CNTs represents a major challenge for clinical application. Various techniques both in vivo and in in vitro have been conducted by a number of different research groups to establish the factors which have a direct effect on CNTmediated cytotoxicity. The main analysis techniques include using Alamar blue, MTT, and Trypan blue assays. Successful interpretation of these results is difficult because the CNTs can significantly disrupt the emission of the certain particles, which these assays detect. In contrast, in vivo studies allow for the measurement of toxicity and pathology caused by CNTs on an organismal level. Despite the drawbacks of in vitro studies, they have been invaluable in identifying important toxicity factors, such as size, shape, purity, and functionalisation, the latter of which can attenuate CNT toxicity.Keywords: carbon nanotubes; toxicology; distribution; administration(Published: 3 December 2013)Citation: Nano Reviews 2013, 4: 21521 - http://dx.doi.org/10.3402/nano.v4i0.21521
 
Publisher Co-Action Publishing
 
Contributor
 
Date 2013-12-03
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
text/html
application/epub+zip
text/plain
 
Identifier http://www.nanoreviewsexperiments.net/index.php/nano/article/view/21521
10.3402/nr.v4i0.21521
 
Source Nano Reviews & Experiments; Vol 4 (2013) incl Supplements
2002-2727
 
Language eng
 
Relation http://www.nanoreviewsexperiments.net/index.php/nano/article/view/21521/31189
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/21521/31190
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/21521/31191
http://www.nanoreviewsexperiments.net/index.php/nano/article/view/21521/31192
 

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