Perspectives on the application of nanotechnology in photodynamic therapy for the treatment of melanoma

Nano Reviews & Experiments

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Title Perspectives on the application of nanotechnology in photodynamic therapy for the treatment of melanoma
Creator Monge-Fuentes, Victoria
Muehlmann, Luis Alexandre
Bentes de Azevedo, Ricardo; Laboratory of Nanobiotechnology, University of Brasilia, Brazil
Subject photodynamic therapy; skin cancer; melanoma; nanoparticles; nanotechnology
Description Malignant melanoma is the most aggressive form of skin cancer and has been traditionally considered difficult to treat. The worldwide incidence of melanoma has been increasing faster than any other type of cancer. Early detection, surgery, and adjuvant therapy enable improved outcomes; nonetheless, the prognosis of metastatic melanoma remains poor. Several therapies have been investigated for the treatment of melanoma; however, current treatment options for patients with metastatic disease are limited and non-curative in the majority of cases. Photodynamic therapy (PDT) has been proposed as a promising minimally invasive therapeutic procedure that employs three essential elements to induce cell death: a photosensitizer, light of a specific wavelength, and molecular oxygen. However, classical PDT has shown some drawbacks that limit its clinical application. In view of this, the use of nanotechnology has been considered since it provides many tools that can be applied to PDT to circumvent these limitations and bring new perspectives for the application of this therapy for different types of diseases. On that ground, this review focuses on the potential use of developing nanotechnologies able to bring significant benefits for anticancer PDT, aiming to reach higher efficacy and safety for patients with malignant melanoma.Keywords: photodynamic therapy; skin cancer; melanoma; nanoparticles; nanotechnologyResponsible Editor: Russ Algar, University of British Columbia, Canada.(Published: 1 September 2014)Citation: Nano Reviews 2014, 5: 24381 -
Publisher Co-Action Publishing
Contributor Brazilian agencies: MCT
INCT Nanobiotechnology.
Date 2014-09-01
Type info:eu-repo/semantics/article

Format application/pdf
Source Nano Reviews & Experiments; Vol 5 (2014) incl Supplements
Language eng

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