CHARACTERISTIC OF CHRONIC MYELOGENOUS LEUKEMIA PATIENTS AT THE POLYCLINIC OF ONCOLOGY, DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA IN 2017

Majalah Biomorfologi

View Publication Info
 
 
Field Value
 
Title CHARACTERISTIC OF CHRONIC MYELOGENOUS LEUKEMIA PATIENTS AT THE POLYCLINIC OF ONCOLOGY, DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA IN 2017
 
Creator Wiyono, M. Rifqi
Bintoro, Siprianus Ugroseno Yudho
Hernaningsi, Yetti
 
Subject Characteristics; Clinical Features; Chronic Myelogenous Leukemia
 
Description Background: Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm because of the reciprocal translocation of chromosome 22 to chromosome 9. In the United States, the incidence of CML is 1.9 cases per 100,000 people. Whereas in Indonesia, there is no specific national data on CML prevalence, especially regarding the clinical profile, even though the cancer cases reach 1.4 per 1,000 population. Objective: To evaluate the characteristics and clinical features of CML patients in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Materials and Methods: This was a cross-sectional descriptive study with data from the medical records of CML patients in 2017 at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. The sample in this study was CML patients with positive Breakpoint Clusters Region- Abelson (BCR-ABL), having a minimum age of 18 years and equipped with epidemiological data, complete blood count data, and peripheral blood smear data. Results: Thirty-three patients met the study criteria. The sample was predominantly male, with a ratio of 1.06 : 1 to female patients with a median age of 40 years. Spleno-megaly was found in 87.9% of the patients. The average results of leukocyte, platelet, and hemoglobin counts were 254.58 x 103/μL, 557 x 103/μL, and 9.55 g/dL. From the results of peripheral blood smear obtained normochromic normocytic anisopoikilo-cytosis erythrocyte (57.6%), all patients had a profile of increased leukocytes with blast presence in 97% of the patients, and 51.5% had a profile of an increase in platelets and the discovery of giant platelets in 33.3% of the patients. Conclusion: The sample was predominantly male with the highest incidence at a younger age range of 21-30 years. The clinical characteristics showed high leukocytosis with various stage of maturation and a tendency to develop grade 2 normocytic normochromic anemia and thrombo-cytosis was found in the patients.
 
Publisher Universitas Airlangga
 
Contributor
 
Date 2020-06-12
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion


 
Format application/pdf
 
Identifier https://e-journal.unair.ac.id/MBIO/article/view/19861
10.20473/mbiom.v30i1.2020.27-33
 
Source Majalah Biomorfologi; Vol 30, No 1 (2020): MAJALAH BIOMORFOLOGI; 27-33
2716-0920
0215-8833
 
Language eng
 
Relation https://e-journal.unair.ac.id/MBIO/article/view/19861/15049
 
Rights Copyright (c) 2020 Majalah Biomorfologi
http://creativecommons.org/licenses/by-nc/4.0
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library