KONTRIBUSI INFLAMASI TERHADAP PATOGENESIS PENYAKIT PARKINSON

Majalah Biomorfologi

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Field Value
 
Title KONTRIBUSI INFLAMASI TERHADAP PATOGENESIS PENYAKIT PARKINSON
 
Creator Maulana, Reza
Kalanjati, Viskasari Pintoko
 
Subject Parkinson’s disease; inflammation; microglia;pro-inflammatory cytokine; Penyakit parkinson; peradangan; mikroglia; sitokin pro-inflamasi
 
Description Parkinson’s disease is one of neurodegenerative diseases which is the second most common afterAlzheimer’s disease in the world. It is a chronic disease with selective loss of dopaminergic neurons withinthe substantia nigra (SN) pars compacta (pc) of the midbrain. The disease represents a complex interactionbetween the inherent vulnerability of the nigrostriatal dopaminergic system, a possible geneticpredisposition, and exposures to environmental toxins including inflammatory triggers. Until now, the exactcause of Parkinson’s disease remains uncertain, but recent studies suggest neuroinflammation andmicroglia activation play important roles in Parkinson’s disease pathogenesis. Evidence now suggest thatchronic neuroinflammation and systemic inflammation are consistently associated with the patophysiologyof Parkinson’s disease. Activated microglia and increased level of pro-inflammatory cytokine such as TumorNecrosis Factor (TNF)-α, interleukin (IL)-2, IL-6, RANTES, Reactive Oxygen Species (ROS) and NitricOxide (NO) have been reported from Parkinson’s disease patients and in animal models of Parkinson’sdisease. The blood brain barrier permeability dysfunction is also a contributing factor to the pathology ofthis disease. In this review, we discuss about neuronal cell pathology in Parkinson’s disease, its possiblerelationship with neuroinflammation and systemic inflammation, blood brain barrier disfunction and proinflammatory cytokine released during the disease’s progressivity. Lastly, we also review theepidemiological data suggest about the inflammation and the increased risk of Parkinson’s disease. Moreresearch are needed to undercover the role of inflammation in Parkinson’s disease. With a betterunderstanding about the relationship between inflammation and Parkinson’s disease cross-talk, the brightfuture with the possibility of specific immunomodulatory drugs play a role to limit a progressivity ofParkinson’s disease is no longer just a dream.
 
Publisher Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga
 
Contributor
 
Date 2019-11-15
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier https://e-journal.unair.ac.id/MBIO/article/view/15911
10.20473/mbiom.v25i2.2012.27-32
 
Source Majalah Biomorfologi; Vol 25, No 2 (2012): Majalah Biomorfologi; 27-32
2716-0920
0215-8833
 
Language eng
 
Relation https://e-journal.unair.ac.id/MBIO/article/view/15911/8579
 
Rights Copyright (c) 2019 Majalah Biomorfologi
http://creativecommons.org/licenses/by-nc-sa/4.0
 

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