EFEK IBUPROFEN ORAL TERHADAP PERUBAHAN BERAT BADAN PADA MENCIT BETINA

Majalah Biomorfologi

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Field Value
 
Title EFEK IBUPROFEN ORAL TERHADAP PERUBAHAN BERAT BADAN PADA MENCIT BETINA
 
Creator Djianto, Anindya Marcha Angelina
Yuliawati, Tri Hartini
Dwiningsih, Sri Ratna
Widjiati, Widjiati
 
Subject Ibuprofen; body weight changes; mice; perubahan berat badan; mencit
 
Description Background: Ibuprofen is one of the most used non-steroidal anti-inflammatory drugs (NSAID) due to its ease of access without the need of prescription. However, ibuprofen may cause side effects associated with gastrointestinal mucosal injury. The discomfort caused when eating may cause nausea and loss of appetite which leads to weight loss. Objective: This study was done to prove changes in body weight after treatment of oral ibuprofen using mice as test subjects. Material and method: This study used pre-test post-test control group design. 33 female BALB/c mice were grouped into 3 groups (P1, P2, P3). P1 is a control group which was given aquadest as placebo, P2 was given 52 mg/kg body weight of oral ibuprofen and P3 was given 104 mg/kg body weight of oral ibuprofen. Treatment lasted for 15 days. Results were analyzed using Kruskal-Wallis test and Mann-Whitney U test in IBM SPSS Statistics 22. Result: 80% of the mice had their body weights decreased with an average decrease of 0.91 g (±2.26) in group P1, average decrease of 2.2 g (±2.15) in P2, and average decreased of 4.11 g (±2.62) in P3. Statistical analysis showed that body weight changes of group P3 has significant difference (p = 0.009) compared to P1 and P2. Conclusion: It can be concluded that 104 mg/kg dose of oral ibuprofen caused a decrease in body weight of female mice.
 
Publisher Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga
 
Contributor
 
Date 2019-11-15
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier https://e-journal.unair.ac.id/MBIO/article/view/16112
10.20473/mbiom.v29i2.2019.27-31
 
Source Majalah Biomorfologi; Vol 29, No 2 (2019): Majalah Biomorfologi; 27-31
2716-0920
0215-8833
 
Language eng
 
Relation https://e-journal.unair.ac.id/MBIO/article/view/16112/8654
 
Rights Copyright (c) 2019 Majalah Biomorfologi
http://creativecommons.org/licenses/by-nc-sa/4.0
 

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