Hepatitis B Screening Prior to Chemotherapy in the Middle East: A Retrospective Cohort Study

The International Arabic Journal of Antimicrobial Agents

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Title Hepatitis B Screening Prior to Chemotherapy in the Middle East: A Retrospective Cohort Study
Creator Ziade, Nathalie
Hosni, Mohammad
Barada, Kassem
Bizri, Abdul Rahman
Description Background: Hepatitis B virus (HBV) reactivation can be asymptomatic or manifest as fatal fulminant hepatitis. Most international guidelines recommend screening patients prior to immunosuppressive therapy.
Aims: To determine HBV screening rates and modalities in patients receiving chemotherapy at the American University of Beirut Medical Center.
Methods: A retrospective cohort review of electronic health records of  adult patients who received chemotherapeutic agents, between June 2015 and June 2016. Patients clinical characteristics were documented. Adequate screening was defined as performing all: HBsAg, HBs Abs, and anti HBc Abs(total).
Results: A total of 1547 patients were initially assessed. 45.6% were males with a mean age of 56. 382(30%) had hematologic malignancies, of whom 111 underwent HSCT. Of those included, 303(24%) patients were screened by at least one test for HBV and 42(3.3%) for HBsAg, anti HBc Abs and HBs Abs.
Patients who were appropriately screened were significantly younger(p=0.008) and more likely to have hematologic malignancies (n=35, 83.3%, p<0.0001). Among patients with hematologic malignancies, appropriately screened patients (n=35) were younger (p=0.042) and had a history of HSCT(n=19, 54.3%, p=0.001).
Conclusion: Rates of screening for HBV prior to chemotherapy at our medical center are low, and not always complete or adequate. There is an urgent need to implement a better screening policy.
Publisher International Medical Publisher
Date 2020-05-07
Type info:eu-repo/semantics/article
Peer-reviewed Article
Format application/pdf
Identifier http://imed.pub/ojs/index.php/IAJAA/article/view/2363
Source The International Arabic Journal of Antimicrobial Agents; Vol 10 No 1 (2020)
Language eng
Relation http://imed.pub/ojs/index.php/IAJAA/article/view/2363/2098
Rights Copyright (c) 2020 Nathalie Ziade, Mohammad Hosni, Kassem Barada, Abdul Rahman Bizri

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