Etiologies of neonatal cholestasis at a tertiary hospital in Bangladesh

Paediatrica Indonesiana

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Title Etiologies of neonatal cholestasis at a tertiary hospital in Bangladesh
Creator Benzamin, Md.
Khadga, Mukesh
Begum, Fahmida
Rukunuzzaman, Md.
Mazumder, Md. Wahiduzzaman
Lamia, Khan Nahid
Islam, Md. Saidul
Rahman, AZM Raihanur
Karim, ASM Bazlul
Description Background Neonatal cholestasis is an important etiology of chronic liver disease in young children. It has a varied etiology. There is considerable delay in presentation and diagnosis of neonatal cholestasis in Bangladesh. Lack of awareness and knowledge among the pediatricians regarding etiological diagnosis and outcome of neonatal cholestasis is the reasons for poor outcome in major portion of cases in Bangladesh.
Objective To evaluate the etiological spectrum of neonatal cholestasis.
Methods This retrospective study was conducted at the Department of Pediatric Gastroenterology and Nutrition, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. We reviewed medical records of children who were diagnosed with neonatal cholestasis. Complete diagnostic profiles of every cases with age of presentation, male-female ratio and final diagnosis were analyzed.
Results A total of 114 children with neonatal cholestasis were evaluated. Subjects’ male-female ratio was 1.92: 1.0, and mean age at hospitalization was 92.7 (SD 39.5) days. Biliary atresia was the most common etiology (47.4%), followed by idiopathic neonatal hepatitis/INH (21.9%). Other identified etiologies were, toxoplasmosis, others (syphilis, varicella-zoster, parvovirus b19), rubella, cytomegalovirus (CMV), and herpes/TORCH infection (8.61%), progressive familial intrahepatic cholestasis/PFIC (4.4%), galactosemia (4.4%), choledochal cyst (3.5%),  sepsis (1.8%), urinary tract infection/UTI (1.8%), hypothyroidism (1.8%), lipid storage disease/Niemann-Pick disease (0.9%), non-syndromic paucity of interlobular bile ducts (2.67%), and Caroli’s disease (0.9%).
Conclusion  In Bangladesh, neonatal cholestasis cases are most often due to obstructive causes, particularly biliary atresia. Idiopathic (INH), infectious (primarily TORCH), metabolic, and endocrine causes followed in terms of frequency.
Publisher Indonesian Pediatric Society
Date 2020-02-28
Type info:eu-repo/semantics/article
Format application/pdf
Source Paediatrica Indonesiana; Vol 60 No 2 (2020): March 2020; 67-71
Language eng
Rights Copyright (c) 2020 Md. Benzamin, Mukesh Khadga, Fahmida Begum, Md. Rukunuzzaman, Md. Wahiduzzaman Mazumder, Khan Nahid Lamia, Md. Saidul Islam, AZM Raihanur Rahman, ASM Bazlul Karim

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