Organ-Protective Effect of Red Ginger Extracts in Male Mice Induced by Paraquat

Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH)

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Title Organ-Protective Effect of Red Ginger Extracts in Male Mice Induced by Paraquat
 
Creator Tsany, Kamiliah; Jurusan Biologi FMIPA Unila
Sutyarso, Sutyarso; Jurusan Biologi, FMIPA, Universitas Lampung1
Kanedi, M.; Jurusan Biologi, FMIPA, Universitas Lampung1
Busman, Hendri; Jurusan Biologi, FMIPA, Universitas Lampung1
 
Subject Red ginger (Zingiber officinale Roxb. Var rubrum); paraquat; antioxidant; liver; lung
 
Description Paraquat is a toxic compound that disrupts biochemical processes in the body, cell death, and multi-organ failure. The liver and lung are the target organ of paraquat toxicity. The body needs antioxidants to counteract free radicals. Red ginger (Zingiber officinale Roxb. Var rubrum) is a spice that contains antioxidants. This study was conducted to determine the effect of ethanol extract of red ginger (Zingiber officinale Roxb. Var rubrum) on liver and lung histology male mice induced by paraquat. The research used completely randomized design and use of 6 treatment groups, i.e. control group (given distilled water and standard feed), PQ group (induced by paraquat 20 mg/kg per BW), group P1 (given paraquat and ethanol extracts of red ginger 200 mg/kg per BW), group P2 (given paraquat and ethanol extract of red ginger 400 mg/kg per BW), group P3 (given paraquat and ethanol extract of red ginger 600 mg/kg per BW), group P4 (given ethanol extract of red ginger extract 600 mg/kg per BW). The data obtained will be tested using One Way ANOVA and continued by Least Significant Difference (LSD) with a 95% confidence level. The results showed ethanol extract of red ginger effective against liver and lung histology male mice induced by paraquat. The results also showed ethanol extract of red ginger with a dose of 400 mg/kg per BW is effective in protecting the liver and lung from damage caused induced by paraquat.
 
Publisher Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Lampung
 
Contributor
 
Date 2019-12-19
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://jurnal.fmipa.unila.ac.id/jbekh/article/view/2377
10.23960/j-bekh.v6i2.2377
 
Source Jurnal Ilmiah Biologi Ekperimen dan Keanekaragaman Hayati (J-BEKH); Vol 6, No 2 (2019); 8-17
Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati; Vol 6, No 2 (2019); 8-17
2686-200X
2338-4344
10.23960/j-bekh.v6i2
 
Language eng
 
Relation http://jurnal.fmipa.unila.ac.id/jbekh/article/view/2377/1718
 
Rights Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
 

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