Bone mineral density and its correlation with Vitamin D status in healthy adults of Manipur – A cross-sectional study

International Journal of Current Research in Physiology and Pharmacology (IJCRPP)

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Title Bone mineral density and its correlation with Vitamin D status in healthy adults of Manipur – A cross-sectional study
 
Creator M, Dr karthika
Bhardwaj, Prakash Chandra
Sharma, Laimayum Amarnath
Kanan, W
Asoka Singh, W
 
Description The levels of vitamin D have an important effect on bone mass in young and old. Hypovitaminosis D adversely affects calcium metabolism, osteoblastic activity, matrix ossification, bone remodeling, and hence bone density. Objective: The present study was conducted to determine the status of serum 25(OH)D and BMD of healthy adult men in Manipur and also to find out the relationship of 25(OH)D level with BMD. Methods: A cross-sectional study was conducted in Department of Physiology in collaboration with the Department of Physical Medicine & Rehabilitation, Regional Institute of Medical Sciences (RIMS), Imphal from October 2014 to September 2016. 100 Healthy adult males in Manipur in the age group 18-35years and ≥50years were included in the study after obtaining Ethical approval from the Research Ethics Board, RIMS, Imphal. The serum 25-OH vitamin D level was estimated by using an enzyme immunoassay (EIA) kit (IDS immunodiagnostic systems, United Kingdom). The BMD of lumbar spine was determined using enCORE – based X-ray bone densitometer (Lunar Prodigy advance, GE Medical Systems, USA) which is based on DEXA scan. Results: The present study revealed that the majority of subjects with insufficiency of 25(OH)D had low bone mass, whereas all the subjects with 25(OH)D deficiency had BMD readings consistent with osteopenia or osteoporosis in both the age groups. This study also showed a positive correlation between BMD and 25(OH)D in most subjects, particularly in the groups with insufficiency or deficiency of 25(OH)D.Conclusion: In conclusion, the study shows a positive relationship between the serum 25 (OH) D concentrations and BMD.
Keywords: Serum 25(OH)D; Bone mineral density (BMD); Enzyme immunoassay (EIA).
 
Publisher Sumathi Publications
 
Date 2020-02-23
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://sumathipublications.com/index.php/ijcrpp/article/view/311
10.31878/ijcrpp.2020.41.02
 
Source International Journal of Current Research in Physiology and Pharmacology (IJCRPP); Volume 4, Issue 1; 2020; 6-9
2523-6709
2523-6695
 
Language eng
 
Relation https://sumathipublications.com/index.php/ijcrpp/article/view/311/359
 
Rights Copyright (c) 2020 Dr karthika M, Prakash Chandra Bhardwaj, Laimayum Amarnath Sharma, W Kanan, W Asoka Singh
http://creativecommons.org/licenses/by-nc-sa/4.0
 

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