ALANINE AMINO TRANSFERASE (ALT) SPECIFIC ACTIVITIES IN LONG TERM SYSTEMIC HYPOXIC RAT BRAIN TISSUES

Acta Biochimica Indonesiana

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Title ALANINE AMINO TRANSFERASE (ALT) SPECIFIC ACTIVITIES IN LONG TERM SYSTEMIC HYPOXIC RAT BRAIN TISSUES
 
Creator Ramadhani, Rizka
Prijanti, Ani Retno
 
Description Background: Brain as a very aerobic organ is sensitive to hypoxia. Energy scarcities must be overcome by gluconeogenesis, which uses alanine or lactate as starting material.  The reaction is catalyzed by alanine amino transaminase (ALAT or ALT), also known as glutamate pyruvate transaminase (GPT).  Objective: To investigate whether the specific activities of alanine aminotransferase (ALT) increased in hypoxic rat brain.Methods: This experimental study used rats exposed to systemic normobaric hypoxia during 14 days. A group of 5 rats was sacrificed in days 1, 3, 7 and 14. The specific activities of ALT were analyzed in their brains using a reaction coupled with lactate dehydrogenase (LDH) activities.Results: The ALT specific activities in rat brain were very low. There was no significant increase of specific activities during long term hypoxia (p > 0.05).Conclusion: The rat brain ALT has no role in gluconeogenesis.
 
Publisher PP PBBMI
 
Contributor
 
Date 2020-02-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://pbbmi.org/jurnal/index.php/ActaBioIna/article/view/43
10.32889/actabioina.v2i2.43
 
Source Acta Biochimica Indonesiana; Vol 2, No 2 (2019): ACTA BIOCHIMICA INDONESIANA
2654-3222
2654-6108
 
Language eng
 
Relation https://pbbmi.org/jurnal/index.php/ActaBioIna/article/view/43/pdf_1
 
Rights Copyright (c) 2020 Ani Retno Prijanti
https://creativecommons.org/licenses/by-nc/4.0
 

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