Green tea extract reduces insulin level and folliculogenesis in insulin-resistant PCOS rats model

Majalah Obstetri & Ginekologi

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Field Value
 
Title Green tea extract reduces insulin level and folliculogenesis in insulin-resistant PCOS rats model
 
Creator Puspita, Irma Maya
Santoso, Budi
Utomo, Budi
 
Subject green tea; insulin levels; folliculogenesis; polycystic ovary syndrome
 
Description Objectives: Polycystic ovary syndrome (PCOS) is an endocrine disorder with still unknown pathophysiology. Insulin resistance is one of major factors that affect the pathogenesis of PCOS (69%). Green tea has compounds that can be used to improve the condition of insulin resistance, so that folliculogenesis may recur in the case of PCOS.Materials and Methods: The subjects in this study were rats which were divided into 5 groups, consisting of 2 groups serving as a control group (negative and positive) and 3 groups as the treatment group. Each group consisted of 7 experimental animals. Negative control group was given with distilled water for 14 days. Positive control group was given with injections of testosterone propionate 1 mg/100 g BW intramuscularly in the thigh for 28 days to obtain a model of insulin-resistant PCOS and the distilled water was used as therapy. The treatment groups were given wth injections of testosterone propionate 1 mg/100gBW intra-muscularly for 28 days and then treated with green tea extract in doses of each 200 mg/kg, 400 mg/kg, and 800 mg/kg for 14 days. Rats were dissected on day 42 for harvesting the right and left ovary and heart blood sample was taken for examining insulin levels.Results: The results showed that administration of green tea extract on K5 can reduce insulin levels and increase folliculogenesis significantly (significance p <0.05).Conclusion: Green tea extract can reduce insulin levels and increase folliculogenesis in rats. PCOS - Insulin resistance at a dose of 800 mg/kg.
 
Publisher Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University
 
Contributor
 
Date 2020-01-22
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://e-journal.unair.ac.id/MOG/article/view/17513
10.20473/mog.V27I32019.103-107
 
Source Majalah Obstetri & Ginekologi; Vol 27, No 3 (2019): December; 103-107
2598-1013
0854-0381
 
Language eng
 
Relation http://e-journal.unair.ac.id/MOG/article/view/17513/9623
 
Rights Copyright (c) 2020 Majalah Obstetri & Ginekologi
http://creativecommons.org/licenses/by-nc-sa/4.0
 

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