Species differences in plasma and tissue concentrations of florfenicol between sheep and rabbits

Revista MVZ Córdoba

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Title Species differences in plasma and tissue concentrations of florfenicol between sheep and rabbits
Diferencias de especie en las concentraciones plasmáticas y tisulares de florfenicol entre ovinos y conejos
Creator Cazanga Reyes, Victoria Matilde
Jeldres Ortiz, Jessie Ana
Palma ibáñez, Cristina Judith
Riquelme Acuña, José Belarmino
Cornejo Díaz, Diego Luis
Pérez Fernández, Rubén
Description Objective. The aim of this study was to compare tissue and plasma concentrations of florfenicol (FFC) and its metabolite florfenicol amine (FFC-a) between sheep and rabbits, after intramuscular administration of 20 mg FFC/kg. Materials and methods. Five Suffolk Down sheep and six New Zealand rabbits were used in this study. Blood samples were collected before FFC administration and at 0.25, 0.5, 1, 1.5, 2, 3 and 4 hours after treatment. At 4 hours after treatment, euthanasia was applied to animals. Plasma and tissue concentrations of FFC and FFC-a were determined by HPLC. Results. For FFC, maximum plasma concentrations, absorption rate, absorption half-life, distribution rate, and area under the plasma concentration-time curve were all found to be significantly higher in rabbits than in sheep. Similarly, for FFC-a, significantly higher maximum plasma concentrations and area under the concentration-time curve were observed in rabbits as compared to sheep. The metabolite ratio was higher in rabbits (12.7±3.07%) compared to sheep (3.99±0.87%) (p<0.05), as were the tissue concentrations of FFC and FFC-a. Conclusions. Significant differences in the pharmacokinetics and tissue concentrations of FFC, and its metabolite FFC-a, were observed between these two animal species. The higher concentrations of FFC-a in rabbits indicate a greater level of FFC metabolism as compared to sheep. This should be considered when establishing dosage and frequency of FFC administration for rabbits.
Objetivo. Comparar las concentraciones plasmáticas y tisulares de florfenicol (FFC) y su metabolito florfenicol amina (FFC-a) entre ovinos y conejos, posterior a la administración intramuscular de 20 mg/kg de FFC. Materiales y métodos. Cinco ovinos Suffolk Down y seis conejos Neozelandés fueron utilizados en el estudio. Se colectaron muestras de sangre, previo a la administración de FFC, y a las 0.25, 0.5, 1, 1.5, 2, 3 y 4 horas posteriores al tratamiento. A las 4 horas posteriores al tratamiento, a los animales se les aplicó la eutanasia. Las concentraciones plasmáticas y tisulares de FFC y FFC-a fueron determinadas mediante HPLC. Resultados. Las concentraciones plasmáticas máximas, tasa de absorción, vida media de absorción, tasa de distribución y área bajo la curva de FFC, fueron significativamente mayores en conejos respecto a los ovinos. Asimismo, para FFC-a, las concentraciones plasmáticas máximas y área bajo la curva de concentraciones plasmáticas en el tiempo fueron significativamente mayores en conejos respecto a los ovinos. La proporción de metabolito fue mayor en conejos (12.7±3.07%) en comparación con ovinos (3.99±0.87%) (p<0.05), al igual que las concentraciones tisulares de FFC y FFC-a. Conclusiones. Se observaron diferencias significativas en la farmacocinética y concentraciones tisulares de FFC y FFC-a entre estas dos especies. La mayor concentración de FFC-a en conejos indica un mayor nivel de metabolismo de FFC, respecto a los ovinos. Esto es importante de considerar al momento de establecer dosificaciones y frecuencia de administración de FFC en conejos.
Publisher Universidad de Córdoba
Date 2019-12-30
Type info:eu-repo/semantics/article
Format application/pdf
Identifier https://revistamvz.unicordoba.edu.co/article/view/e1699
Source Journal MVZ Cordoba; Journal MVZ Córdoba Volume 24 (1) January-April 2020; 1-10
Revista MVZ Córdoba; Revista MVZ Córdoba Volumen 25(1) Enero-abril 2020; 1-10
Language spa
Relation https://revistamvz.unicordoba.edu.co/article/view/e1699/2357

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