Analysis of carbamazepine side effects associated with bone metabolism, folate and vitamin B12 serum levels in Isfahan epileptic patients

American Journal of Experimental and Clinical Research

View Publication Info
 
 
Field Value
 
Title Analysis of carbamazepine side effects associated with bone metabolism, folate and vitamin B12 serum levels in Isfahan epileptic patients
 
Creator Najafi, Mohamad-Reza
Tolou-Ghamari, Zahra
 
Subject Medicine
Carbamazepine; homocysteine; bone metabolism; folate
Neurobiochemistry
 
Description According to previous publications, chronic uses of AEDs reduce bone health, increase homocysteine levels, alkaline phosphates and many other biochemical changes. The aim of this study was to investigate carbamazepine (CBZ) effects on bone density, serum levels of folate, vitamin B12 and other biochemical variables. Twenty-one adult epileptic patients who received CBZ for treatment of epileptic attacks were enrolled. Bone mineral density (BMD) was evaluated by dual-energy X-ray absorptiometry method. Biochemical indices of bone metabolism, including serum calcium, phosphorus, alkaline phosphatase contents and also serum levels of folate, vitamin B12, homocysteine were measured. All clinical, laboratory and pharmacological data were recorded in d-Base and analyzed using SPSS (version 16) for windows. BMD Z-scores, and 25-dihydroxyvitamin D3 concentrations was not differ significantly, but it seems that, the female patients had diminished BMD at the femoral neck (p≤ 0.05). Folate or vitamin B12 levels tend toward lower values. This seems to be connected to a tendency toward higher mean corpuscular volume (MCV) with a mean of 84.9 fl (ranged from 59-120 fl). TWithin the population studied, there was no correlation between CBZC0 and homocysteine levels (p≤ 0.63). In compare to normal value the serum calcium content was lower with a mean of 7.8 mg/dl (ranged; 7.0-8.9 mg/dl; p ≤ 0.04). With a mean of 213 U/L serums alkaline phosphatase was significantly higher (p ≤ 0.01) than normal values. Due to the need for chronic prescription strategy in order to control convulsion attack, pharmacotherapy with AEDs may consequence to changes in serum contents of calcium, phosphorus, alkaline phosphatase in addition to decrease in BMD and increase in homocysteine levels. Further studies related to efficacy and side-effects of CBZ as the most prescribed AEDs in Iranian epileptic population seem to be valuable.
 
Publisher American Journal of Experimental & Clinical Research
 
Contributor Isfahan University of Medical Sciences supported this study
 
Date 2016-07-04
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
Clinical Medicine
 
Format application/pdf
 
Identifier http://journals.sfu.ca/ajecr/index.php/ajecr/article/view/75
 
Source American Journal of Experimental and Clinical Research; Vol 3, No 3 (2016); 175-179
2330-9245
2330-9237
 
Language eng
 
Relation http://journals.sfu.ca/ajecr/index.php/ajecr/article/view/75/166
 
Rights Copyright (c) 2016 American Journal of Experimental and Clinical Research
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2016 Simon Fraser University Library