Inhibitory Activity of Levofloxacin against MDR Staphylococcus aureus and Pseudomonas aeruginosa Clinical Isolates

Jurnal Farmasi dan Ilmu Kefarmasian Indonesia

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Title Inhibitory Activity of Levofloxacin against MDR Staphylococcus aureus and Pseudomonas aeruginosa Clinical Isolates
 
Creator Nathalie, Lisa
Alimsardjono, Lindawati
Isnaeni, Isnaeni
 
Subject
levofloxacin, MDR, Pseudomonas aeruginosa, Staphylococcus aureus
 
Description Introduction: Staphylococcus  aureus  and  Pseudomonas  aeruginosa  are the most dangerous  and important species among  their genus.  These  bacteria  are often  resistant  to  many  classes  of antimicrobial  agents;  which  make difficulties in selecting appropriate drug to treat infections. Multidrug-resistance occurs readily in hospitals for which antimicrobials  agents  were   used  widely. Objective: The  aims  of  this  study  was  to  determine  minimum  inhibitory concentration  (MIC) and  minimum bacterial  concentration  (MBC) of levofloxacin  against 22 multidrug  resistant- clinical (MDR) strains of Staphylococcus aureus and Pseudomonas aeruginosa isolated from patients pus and urine in hospital. Methods: Determination of the MIC was performed by macro-dilution broth assay as recommended by Clinical and Laboratory Standards Institute (CLSI), while the MBC was determined one-step further after the MIC determination. Results: It was found that MIC of the levofloxacin were (0.3 ± 0.0) - >0.5 µg/mL and (0.2 ± 0.1) - (1.0 ±0.0)µg/mL against S. aureus from pus and urine, respectively.  In addition, higher MICs were yielded against P. aeruginosa, (1.0 ± 0.0) - >8.0 µg/mL and (0.7 ± 0.3) - (3.0 ± 1.2) µg/mL for pus and urine isolates respectively. Similar to MICs, the MBCs against P. aeruginosa were higher than S. aureus, (0.6 ± 0.0) - > 4.0 µg/mL and (0.3 ± 0.0) - >8.0 µg/mL isolated from pus and urine respectively, (2.0 ± 0.6) - > 8.0 µg/mL and (3.0 ± 1.2) - >7.0 µg/mL against P. aeruginosa from pus and urine respectively. Conclusion: The levofloxacin was still susceptible as bacteriostatic against isolates from both body fluids, but not bactericidal towards all isolates.
 
Publisher Fakultas Farmasi Universitas Airlangga
 
Contributor
 
Date 2019-07-31
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://e-journal.unair.ac.id/JFIKI/article/view/13024
10.20473/jfiki.v6i12019.25-31
 
Source JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA; Vol 6, No 1 (2019): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA; 25-31
2580-8303
2406-9388
 
Language eng
 
Relation https://e-journal.unair.ac.id/JFIKI/article/view/13024/8055
https://e-journal.unair.ac.id/JFIKI/article/downloadSuppFile/13024/2479
 
Rights Copyright (c) 2019 JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
http://creativecommons.org/licenses/by-nc-sa/4.0
 

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