Effects of alpha, beta momorcharin fruit extract with the combination of paclitaxel in the treatment of glioma cancer in-vivo.

International Journal of Current Research in Physiology and Pharmacology (IJCRPP)

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Title Effects of alpha, beta momorcharin fruit extract with the combination of paclitaxel in the treatment of glioma cancer in-vivo.
 
Creator MANOHARAN, GUNASEKAR
 
Description The vegetable Momordica charantia L., (family: Cucurbitaceae) is a scientific name of the plant and its fruit. It is also known by other names, for instance in the USA it is known as Bitter gourd or balsam pear while its referred to as the African cucumber in many African countries.  M.charantiais believed to posse’s anti-carcinogenic properties and it can modulate its effect via xenobiotic metabolism and oxidative stress. This study was specifically designed to investigate the cellular mechanisms whereby α, β momorcharin an extract of M. charantiacan induce cell death with the combination of paclitaxel.  Different concentration (200µM - 1000µM)of the α, β momorcharin fruit extract were treated (24 hrs incubation) separately with three different cancer cell lines 1321N1, Gos-3, U87-MG and normal L6 muscle cell line. The results also show that paclitaxel(250 µg) with (1000 µM) of the α, β momorcharinextract of M. Charantia,and result in significant decreases in cell viability for each cell line, these effects were additive compared to the individual effect of paclitaxel.  
 
 
Publisher Sumathi Publications
 
Date 2019-04-21
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier https://sumathipublications.com/index.php/ijcrpp/article/view/269
10.31878/ijcrpp.2019.32.1
 
Source International Journal of Current Research in Physiology and Pharmacology (IJCRPP); Volume 3, Issue 2; 2019; 2-6
2523-6709
2523-6695
 
Language eng
 
Relation https://sumathipublications.com/index.php/ijcrpp/article/view/269/302
 
Rights Copyright (c) 2019 GUNASEKAR MANOHARAN
http://creativecommons.org/licenses/by-nc-sa/4.0
 

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