ENHANCING COGNITIVE FUNCTION OF HEALTHY WISTAR RATS WITH AQUEOUS EXTRACT OF Centella asiatica

Acta Biochimica Indonesiana

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Field Value
 
Title ENHANCING COGNITIVE FUNCTION OF HEALTHY WISTAR RATS WITH AQUEOUS EXTRACT OF Centella asiatica
 
Creator Rosdah, Ayeshah A
Lusiana, Evi
Reagan, Muhammad
Akib, Abdurrahman
Khairunnisa, Fadhila
Husna, Afkara
 
Description Background: Centella asiatica (L.) Urb is a native herb from Asian countries such as India, China, and Indonesia. This herb has been widely used as a cure for various diseases. However, studies investigating the aqueous extract of Centella asiatica as a nootropic in healthy individuals are still very limited.Objective: This study aims to investigate the potential of aqueous extract of Centella asiatica in enhancing cognitive function of healthy male Wistar rats.Methods: Rats were randomly allocated to four treatment groups, i.e. without treatment and aqueous Centella asiatica extract at doses of 200, 400 and 800 mg/kg. To determine enhancement of cognitive function, novel object recognition (NOR) test was conducted after the course of treatment. Acetylcholine content was assessed by enzyme-linked immunosorbent assay.Results: There was a significantly high preference index towards the novel object in the NOR test in groups treated with 200 mg/kg and 800 mg/kg of the aqueous extract compared to control. This was further confirmed by a significant increase of brain acetylcholine content in rats treated with 200 mg/kg of the extract.Conclusion: Therefore, this study confirms that the aqueous extract is effective in enhancing cognitive performance of healthy Wistar rats.
 
Publisher PP PBBMI
 
Contributor
 
Date 2019-01-16
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://pbbmi.org/jurnal/index.php/ActaBioIna/article/view/15
10.32889/actabioina.v1i2.15
 
Source Acta Biochimica Indonesiana; Vol 1, No 2 (2018): ACTA BIOCHIMICA INDONESIANA; 37-45
2654-3222
2654-6108
 
Language eng
 
Relation https://pbbmi.org/jurnal/index.php/ActaBioIna/article/view/15/pdf
 
Rights Copyright (c) 2019 Ayeshah A Rosdah, Evi Lusiana, Muhammad Reagan, Abdurrahman Akib, Fadhila Khairunnisa, Afkara Husna
https://creativecommons.org/licenses/by-nc/4.0
 

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