In vitro ANTIMALARIAL ACTIVITY OF Pergularia daemia (L.) AGAINST CHLOROQUINE-SENSITIVE (3D7) AND CHLOROQUINE-RESISTANT (K1) STRAINS OF Plasmodium falciparum

Uttar Pradesh Journal of Zoology

View Publication Info
 
 
Field Value
 
Title In vitro ANTIMALARIAL ACTIVITY OF Pergularia daemia (L.) AGAINST CHLOROQUINE-SENSITIVE (3D7) AND CHLOROQUINE-RESISTANT (K1) STRAINS OF Plasmodium falciparum
 
Creator BRAHMAM, P.
SUNITA, K.
KUMAR, N. RAVI
SRAVANI, G.
 
Description Objective: To find out the in vitro antiplasmodial activity of Pergularia daemia leaf extract against Plasmodium falciparum chloroquine sensitive 3D7 strain and Plasmodium falciparum chloroquine resistant K1 strain and cytotoxicity against Vero cell line.
Methods: The P. daemia plant was collected from Kadaparajupalle at Dornala mandal, Prakasam District, Andhra Pradesh, India. Leaf crude extracts prepared in Soxhlet apparatus with hexane, chloroform and methanol solvents. These extracts were tested for in vitro antiplasmodial activity against 3D7 and K1 strains by standard laboratory protocol. In vitro Cytotoxicity of the leaf extract was also tested by following standard laboratory method.
Results: Hexane, chloroform and methanolic extracts of leaf shown good antiplasmodial activity against 3D7 strain i.e., hexane leaf extract shown IC50 of 11.04 µg/ml, chloroform leaf extract of 7.98 µg/ml and methanolic leaf extract of 6.33 µg/ml. Hexane, chloroform and methanolic extracts showed very active antiplasmodial activity against K1 strain with IC50 values of 4.79 µg/ml, 4.01 µg/ml and 2.91 µg/ml respectively. And all the leaf extracts were non-toxic against Vero cell line with CC50 >20 µg/ml.
Conclusion: The methanolic extract of leaf is effective and shown excellent antimalarial activity for the development of new antimalarial drug policies.
 
Publisher MB International Media and Publishing House
 
Date 2019-04-04
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier http://mbimph.com/index.php/UPJOZ/article/view/1399
 
Source UTTAR PRADESH JOURNAL OF ZOOLOGY; 2019 - Volume 39 [Issue 2]; 55-64
0256-971X
0256-971X
 
Language eng
 
Relation http://mbimph.com/index.php/UPJOZ/article/view/1399/1338
 
Rights Copyright (c) 2019 © Copyright MB International Media and Publishing House. All rights reserved.
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library