Role of Non-Vitamin K Oral Anticoagulants for Prevention of Stroke in Renal Impaired Atrial Fibrillation Patients

ACI (Acta Cardiologia Indonesiana)

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Field Value
 
Title Role of Non-Vitamin K Oral Anticoagulants for Prevention of Stroke in Renal Impaired Atrial Fibrillation Patients
 
Creator Setianto, Budi Yuli
 
Subject
 
Description Atrial fibrillation (AF) and chronic kidney disease (CKD) are highly prevalent, particularly with increasing of age and associated comorbidities, such as hypertension, diabetes, heart failure, and vascular disease. The relationship between AF and CKD seems to be bidirectional. CKD predisposes to AF while onset of AF seems to lead to progression of CKD. Stroke prevention is the cornerstone of AF management, and AF patients with CKD are at higher risk of stroke, mortality, cardiac events, and bleeding. Stroke prevention requires use of oral anticoagulants, which are either vitamin K antagonists (e.g. warfarin), or the non-vitamin K antagonist oral anticoagulants (NOAC). While NOAC have been shown to be effective in mild-to-moderate renal dysfunction, there are a paucity of data regarding NOAC in severe and end-stage renal dysfunction. The followingwill discuss the evidence for NOAC in CKD, and summarize the current knowledge regarding the efficacy and safety of NOAC to prevent AF-related stroke and systemic embolism in severe and end-stage renal disease.
 
Publisher Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada
 
Contributor
 
Date 2019-07-18
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier https://jurnal.ugm.ac.id/jaci/article/view/47677
10.22146/aci.47677
 
Source ACI (Acta Cardiologia Indonesiana); Vol 5, No 1 (P) (2019): Proceedings Jogja Cardiology Update 2019 (JCU2019); 17-25
2579-4345
2460-5700
 
Language eng
 
Relation https://jurnal.ugm.ac.id/jaci/article/view/47677/24880
 
Rights Copyright (c) 2019 Budi Yuli Setianto
http://creativecommons.org/licenses/by-sa/4.0
 

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