Botulinum toxin type A (BTX-A) to improve the treatment of keloid and hypertrophic scars: A double-blinded randomized clinical trial

Bali Medical Journal

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Field Value
 
Title Botulinum toxin type A (BTX-A) to improve the treatment of keloid and hypertrophic scars: A double-blinded randomized clinical trial
 
Creator Habibi, Imam; AJA University of Medical Sciences
Taheri, Allahyar; AJA University of Medical Sciences
Hedayatyanfard, Keshvad; Shahid Beheshti University of Medical Sciences
Farazmand, Farzaneh; Islamic Azad University
Habibi, Behnam; Shahid Beheshti University of Medical Sciences
 
Subject
Botulinum toxin type A, keloid, hypertrophic scars.
 
Description Background: Keloid and hypertrophic scars are the results of abnormal skin cells proliferation that usually cause major physical, psychological and cosmetic problems. However, there is no effective method for eliminating this scars yet. Recent reports suggested that BTX-A improves wound healing. However, there is no comprehensive study to assess the efficacy of BTX-A injection for treatment of keloid and hypertrophic scars.Aim: This study aims to investigate whether BTX-A injection improves the keloid and hypertrophic scars treatment or not.Methods: Ten patients with keloid or hypertrophic scar lesions were enrolled in this study and randomized into two groups (injected by BTX-A or placebo). Injections were applied at one-month intervals for a total of three months. All the patients were followed up for at least six months. Scars were assessed by mVSS (modified Vancouver Scar Scale) and an independently blinded evaluator with standardized photographs.Results: The study was completed with ten patients at the six months follow up visits in the treatment group. BTX-A reduced (not significantly, p>0.09) mVSS including pliability, vascularity, pigmentation, and height, but did not affect the pruritis and pain.Conclusion: It can be concluded in this study that BTX-A can reduce some parameters of mVSS and may be a suitable compound for the treatment of keloid and scar tissue.
 
Publisher DiscoverSys Inc.
 
Contributor
 
Date 2019-04-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier https://www.balimedicaljournal.org/index.php/bmj/article/view/1216
10.15562/bmj.v8i1.1216
 
Source Bali Medical Journal; Vol 8, No 1 (2019): (Available online 1 April 2019); 30-34
2302-2914
2089-1180
 
Language eng
 
Relation https://www.balimedicaljournal.org/index.php/bmj/article/view/1216/pdf
 
Rights Copyright (c) 2019 Bali Medical Journal
http://creativecommons.org/licenses/by-nc-nd/4.0
 

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