Exposure of Murattal Al-Quran Audio Enhances Cisplatin Activity on Growth Inhibition and Cell Cycle Modulation on Hela Cells

Indonesian Journal of Cancer Chemoprevention

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Field Value
 
Title Exposure of Murattal Al-Quran Audio Enhances Cisplatin Activity on Growth Inhibition and Cell Cycle Modulation on Hela Cells
 
Creator Mutiah, Roihatul
Mustofa, Muhammad Ragib
Indrawijaya, Yen Yen Ari
Hakim, Abdul
Annisa, Rahmi
Susanti, Nurlaili
Nashichuddin, Ach
Zainuddin, Muhammad
 
Description Cancer is a disease characterized by abnormal cell mechanisms. The development of alternative cancer treatments is still needed. One of them is the music therapy. The music therapy uses sound vibrations to improve healing. Al-Quran, the Holy book of muslims, recites with measured recitation produces beautiful tones. Reading and recitating of Al-Quran is an important form of worship for which a Muslim can expect reward and benefit in the Hereafter. Al-Fatihah is one of surahs in Al-Qur'an that is often read by Muslims and used as a prayer for healing. The purpose of this study was to determine the effect of cytotoxic activity and cell cycle modulation on Hela cells with exposure of murattal Al-Quran and cisplatin combination. Audio exposure murattal Al-Fatihah and its combination with cisplatin to HeLa cells were tested using the MTT method assay. Induction of apoptosis and modulation of cell cycle evaluated by flow cytometry method. Treatment used 30 minutes Audio Murattal (AM), Cisplatin 10 µg/mL (Cis), and the combination of AM + Cis caused a decrease in the viability of HeLa cells respectively 80.14%, 69.86%, and 64.32%. The results of flow cytometry explained that in treatment of AM there was inhibition in the G2-M phase and induction of apoptosis in the M5 phase. Whereas in treatment AM + Cis inhibition occurs in the S, G2-M phase, and induction of apoptosis in the M5 phase. Audio Murattal Al-Quran presents cytotoxic effects on HeLa cells and to provide a synergistic impact on cisplatin so that disclosure therapy murattal can be recommended for supporting therapy in the treatment of cancer (supportive therapy).Keywords: Al-Quran, Audio murottal, HeLa Cells, Cell Viability, Flow cytometry
 
Publisher Indonesian Society for Cancer Chemoprevention
 
Contributor Lp2M UIN Maulana Malik Ibrahim Malang
 
Date 2019-07-09
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier https://ijcc.chemoprev.org/index.php/ijcc/article/view/268
10.14499/indonesianjcanchemoprev10iss2pp71-79
 
Source Indonesian Journal of Cancer Chemoprevention; Vol 10, No 2 (2019); 71-79
2355-8989
2088-0197
 
Language eng
 
Relation https://ijcc.chemoprev.org/index.php/ijcc/article/view/268/185
 
Rights Copyright (c) 2019 Roihatul Mutiah, Muhammad Ragib Mustofa, Yen Yen Ari Indrawijaya, Abdul Hakim, Rahmi Annisa, Nurlaili Susanti, Ach Nashichuddin, Muhammad Zainuddin
 

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