THE EFFECTS OF HYPERTENSION STAGES ON N-TERMINAL-PRO BRAIN NATRIURETIC PEPTIDE (NT-PRO-BNP) LEVEL AND LEFT VENTRICULAR EJECTION FRACTION

Sains Medika

View Publication Info
 
 
Field Value
 
Title THE EFFECTS OF HYPERTENSION STAGES ON N-TERMINAL-PRO BRAIN NATRIURETIC PEPTIDE (NT-PRO-BNP) LEVEL AND LEFT VENTRICULAR EJECTION FRACTION
 
Creator Sriwiyati, Kati
 
Subject Hypertension stage, NT-proBNP, left ventricular ejection fraction, chronic heart failure
 
Description Background: Hypertension is the most common risk factor for heart failure causing an increase in N-Terminal-Pro Brain Natriuretic Peptide (NT-proBNP) level and a decrease in left ventricular ejection fraction (LVEF). Objective: To investigate the effect of hypertension on NT-proBNP level and LVEF in patients with chronic heart failure.Method: This cross sectional study takes 29 people with hypertension stage-1 (HTD-1) and 27 people with hypertension stage-2 (HTD-2) as sample. The left ventricular ejection fraction and NT-proBNP level obtained from medical records are analyzed using independent t test and Mann Withney test, followed with Spearmen correlation between NT-proBNP level and LVEF.Results: Mann-Whitney test indicates that the mean value of NT-proBNP level of HTD-2 is significantly higher compared to that of HTD-1, p = 0,000. On the contrary, the independent t test shows that LVEF in HTD-2 is lower than that of HDT-1, p = 0.001. The Spearman correlation analysis conducted on the NT-proBNP level and the LVEF results in value of -0.651, p = 0.000. The cut-off-point value of NT-proBNP level is 1511pg/ml (sensitivity 0.82% and specificity 0.80%) and the value of area under the ROC curve > 0.7. The left ventricular ejection fraction has an area under the ROC curve > 0.7 with a cut-off-point value of 39% (sensitivity 0.67% and specificity 0.69%).Conclusion: The NT-proBNP level and the LVEF of HTD-2 are significant higher and lower respectively compared to those of HTD-1. The NT-proBNP level and LVEF also show a strong negative correlation. The cut-off-point value of NT-proBNP level and LVEF can be utilized to compare the stages of hypertension in patients with chronic heart failure.Keywords: Hypertension stage, NT-proBNP, left ventricular ejection fraction, chronic heart failure.
 
Publisher Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)
 
Contributor
 
Date 2019-07-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Identifier http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/3379
10.26532/sainsmed.v10i1.3379
 
Source Sains Medika: Jurnal Kedokteran dan Kesehatan; Vol 10, No 1 (2019): January - June 2019
2339-093X
2085-1545
10.26532/sainsmed.v10i1
 
Language id
 
Rights Copyright (c) 2019 Sains Medika: Jurnal Kedokteran dan Kesehatan
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library