The effect of Gandarusa Leaf extract (Justicia gendarussa Burm F.) Administration on Estradiol Hormone Level and the Amount of Antral Ovarium Follicle on Female Mice

Sains Medika

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Title The effect of Gandarusa Leaf extract (Justicia gendarussa Burm F.) Administration on Estradiol Hormone Level and the Amount of Antral Ovarium Follicle on Female Mice
 
Creator hidayatullaili, ni'mah
 
Subject
 
Description  Background: Physiologically, woman experiencing aging characterized by menopause. Gandarusa leaf contains isoflavon, a phytoesterogen expected to be used as esterogen replacement therapy. Objective: the aim of this research is to investigate the administrative effect of gandarusa leaf extract on the increase of estradiol hormone level and the number of antral ovarium follicle of female mice.Methods: This is experimental study with posttest only control group research design. Samples are 24 balb-c female mice, aged 16-17 months, weighed 19-35 grams, divided into 4 groups. Control group (Ctrl-G) were given 0.48 ml aquadest; group JB10-G, JB20-G, and JB30-G, each were given gandarusa leaf extract with concentration 10%, 20%, dan 30% in volume 0.48 ml orally twice a day. After treatment, dissection were conducted to make ovarium histology preparation with Hematoxylin Ehrlich-Eosin staining, observation were conducted using microscope. Results: Post hoc analysis indicated that the estradiol level and the number of antral ovarium follicle on administration of gandarusa leaf extract with concentration 10%, 20%, dan 30% are significantly higher, p < 0.05. The increase of estradiol level with extract concentration of 10% are significantly negatively correlated with the number of antral ovarium follicles p<0.05. Conclusion: The administration of gandarusa leaf extract increase the estradiol hormone level and the number of antral ovarium follicle in female mice. Keywords : gandarusa leaves extract, estradiol endogenous, ovary histology
 
Publisher Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)
 
Contributor
 
Date 2018-12-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Identifier http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/2099
10.26532/sainsmed.v9i2.2099
 
Source Sains Medika: Jurnal Kedokteran dan Kesehatan; Vol 9, No 2 (2018): July-Desember 2018
2339-093X
2085-1545
10.26532/sainsmed.v9i2
 
Language id
 
Rights Copyright (c) 2019 Sains Medika
http://creativecommons.org/licenses/by/4.0
 

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