The Role of Exercise and Mitochondrial Biogenesis in Aging Process

Sains Medika

View Publication Info
 
 
Field Value
 
Title The Role of Exercise and Mitochondrial Biogenesis in Aging Process
 
Creator Nasihun, Taufiqurrachman
 
Subject
 
Description Aging can be defined as the progressive accumulation of changes with time associated with increasing vulnerability to disease and death which accompanies advancing age. The time related changes are attributed to aging process (Harman, 1981). There are growing evidences that a number of the detrimental free radical reactions are continuously occur throughout the cells of the body constitutes the prominent contributor to aging process (Harman, 1981). This theory was extended to mitochondrial theory of aging, suggesting that mitochondria is the main source and target of reactive oxygen species (ROS) produced in association with aging processes and degenerative diseases (Payne and Chinnery, 2015). Mitochondria has a pivotal roles in multiple cellular processes such as oxidative phosphorylation (OXPHOS), apoptosis,  -oxidation of fatty acids, steroid biosynthesis, calcium homeostasis, intermediary metabolism, and cell signaling (Yin and Cadenas, 2015). Recent studies indicated that oxidative damage due to accumulation of ROS result from mitochondria production were associated with multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging (Cedikova et al., 2016).
 
Publisher Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)
 
Contributor
 
Date 2018-06-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/4871
10.26532/sainsmed.v9i1.4871
 
Source Sains Medika: Jurnal Kedokteran dan Kesehatan; Vol 9, No 1 (2018): January - June 2018
2339-093X
2085-1545
10.26532/sainsmed.v9i1
 
Language eng
 
Relation http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/4871/pdf
 
Rights Copyright (c) 2019 Sains Medika: Jurnal Kedokteran dan Kesehatan
 

Contact Us

The PKP Index is an initiative of the Public Knowledge Project.

For PKP Publishing Services please use the PKP|PS contact form.

For support with PKP software we encourage users to consult our wiki for documentation and search our support forums.

For any other correspondence feel free to contact us using the PKP contact form.

Find Us

Twitter

Copyright © 2015-2018 Simon Fraser University Library