GENOTOXICITY OF CERIUM OXIDE NANOPARTICLE IN ZEBRAFISH AND GREEN MUSSEL PERNA VIRIDIS USING ALKALINE COMET ASSAY

LIFE: International Journal of Health and Life-Sciences

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Field Value
 
Title GENOTOXICITY OF CERIUM OXIDE NANOPARTICLE IN ZEBRAFISH AND GREEN MUSSEL PERNA VIRIDIS USING ALKALINE COMET ASSAY
 
Creator Bhagat, Jacky
S S, Greeshma
Shyama, S K
 
Subject Single Cell Gel Electrophoresis
Nanoceria
DNA Damage
Zebrafish
Green Mussel
 
Description Cerium oxide nanoparticles or nanoceria has versatile application in biomedical, solar cells and gas sensors. Increasing utilization of nanoceria has raised concerns over its release to environment and potential exposure. In vitro studies have shown its genotoxic potential, but reports on aquatic life are very limited. In this study, zebrafish (Danio rerio) and green mussel (Perna viridis) was exposed to different concentration 10, 20, 50 µg/l of nanoceria for 24, 72, and 120 h and the genotoxic response was measured using comet assay. The results showed significant (p < 0.05) increase in tail DNA (TDNA) and olive tail moment (OTM) as measured using comet assay in exposed animals as compared to control. The highest TDNA and OTM were measured after 120 h of exposure with 50 µg/l of nanoceria in zebrafish as well as in green mussel. The results of this study demonstrate that short-term exposure to nanoceria causes a genotoxic response in zebrafish and green mussel, hence its environmental release should be carefully monitored.          Article DOI: https://dx.doi.org/10.20319/lijhls.2019.43.118127 This work is licensed under the Creative Commons Attribution-Non-commercial 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA.
 
Publisher GRDS Publishing
 
Date 2019-02-02
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://grdspublishing.org/index.php/life/article/view/1783
 
Source LIFE: International Journal of Health and Life-Sciences; Vol 4 No 3 (2018): Regular Issue
2454-5872
 
Language eng
 
Relation https://grdspublishing.org/index.php/life/article/view/1783/2961
 
Rights Copyright (c) 2019 Author(s)
 

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