ASSESSMENT OF HEMOSTATIC ACTIVITY OF THE AQUEOUS EXTRACT OF LEAVES OF MARRUBIUM VULGARE L, A MEDITERRANEAN LAMIACEAE ALGERIA

LIFE: International Journal of Health and Life-Sciences

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Title ASSESSMENT OF HEMOSTATIC ACTIVITY OF THE AQUEOUS EXTRACT OF LEAVES OF MARRUBIUM VULGARE L, A MEDITERRANEAN LAMIACEAE ALGERIA
 
Creator Ghedadba, Nabil
Hambaba, Leila
Fercha, Nassima
Houas, Bousselsela
Abdessemed, Samira
Mokhtar, Sidi Mohamed Ould
 
Subject Marrubium Vulgare L
Aqueous Extract
Phenolic Compounds Dosing
Hemostatic Activity
Condensed Tannins
 
Description The overall objective of this study was to evaluate in vitro the hemostatic activity of secondary metabolites (polyphones, flavonoïds and tannins) of Marrubium vulgare leaves, aromatic plant widely used in traditional medicine for the treatment of asthma, cough, diabetes ( by its effect on the pancreas to secrete insulin), heart disease, fever has a high efficiency as against inflammation. Qualitative analysis of the aqueous extract (AQE ) by thin layer chromatography revealed the presence of quercetin, kaempferol and rutin. Quantification of total phenols by Folin Ciocalteu method and flavonoïds by AlCl3 method gave high values with AQE: 175 ± 0.80 mg GAE per 100g of the dry matter, 23.86 ± 0.36 mg QE per 100g of dry matter. Moreover, the assay of condensed tannins by the vanillin method showed that AQE contains the highest value: 16.55 ± 0.03 mg E-Catechin per 100g of dry matter. Assessment of hemostatic activity by the plasma recalcification method (time of Howell) has allowed us to discover the surprising dose dependent anticoagulant effect of AQE lyophilized from leaves of M. vulgare. A positive linear correlation between the two parameters studied: the content of condensed tannins and hemostatic activity (r = 0.96 ) were used to highlight a possible role of these compounds that are potent vasoconstrictor activity in hemostatic. From these results we can see that Marrubium vulgre could be used for the treatment of health. Article DOI: https://dx.doi.org/10.20319/lijhls.2016.s21.253258 This work is licensed under the Creative Commons Attribution-Non-commercial 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA.
 
Publisher GRDS Publishing
 
Date 2016-01-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://grdspublishing.org/index.php/life/article/view/177
 
Source LIFE: International Journal of Health and Life-Sciences; Vol 2 No 1 (2016): Special Issue
2454-5872
 
Language eng
 
Relation https://grdspublishing.org/index.php/life/article/view/177/3389
 
Rights Copyright (c) 2017 Author(s)
 

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