EFFICACY OF THREE MANGROVE PLANTS AGAINST 5-LIPOXYGENASE, ACETYLCHOLINESTERASE ENZYMES AND FIVE PATHOGENIC BACTERIAL STRAINS

LIFE: International Journal of Health and Life-Sciences

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Title EFFICACY OF THREE MANGROVE PLANTS AGAINST 5-LIPOXYGENASE, ACETYLCHOLINESTERASE ENZYMES AND FIVE PATHOGENIC BACTERIAL STRAINS
 
Creator Eldeen, Ibrahim MS.
Napiah, Nor Emera .M.
Mohamad, Habsah
 
Subject Mnagroves
Natural Products
Inflammation Lipoxyygenase
 
Description Mangroves are highly productive ecosystem with various important economic and environmental functions. They are the key elements in marine environment that produce diverse metabolites to adapt with the requirement of their challenging ecosystem. This make them an interesting source for natural bioactive molecules. In this study, we investigated inhibitory effects of extracts from Avicenna lanata, Ceriops tagal and Sonneratia alba against 5-lipoxygenase, acetylcholinesterase enzymes and four pathogenic bacterial strains using in vitro models. Best dual inhibitory effects against the two enzymes was recorded for the methanolic and ethylacetate bark extracts (final concentration used in the assay was 90 μg/ml) of Sonneratia alba and dichlro-root extarct of C.tagal (inhibition percentage ranging between 74-91%). Roots of Ceriops tagal showed the highest activity against lipoxygenase (93%), but was slightly weaker against AchE (83%).Antimicrobial properties of the extracts was determined using the microdilution assay. A. lananta (bark) showed the best antimicrobial efects with the lowest minimum inhibitory concentration (MIC) value of 90 μg/ml against S.aureus, E.coli and K. pneumoniae. Methanolic root and leaf extracts of C.tagal showed the same MIC values against S.aureus. Phytochemical analysis indicated the presence of alkaloids, steroids and tannins in the investigated plant parts. These results support the ethnobotanical uses of these plants. Chemical profiling, isolation and determination of mechanism of actions of the observed bioactivities are currently in progress in our laboratory. Article DOI: https://dx.doi.org/10.20319/lijhls.2015.11.2437 This work is licensed under the Creative Commons Attribution-Non-commercial 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA.
 
Publisher GRDS Publishing
 
Date 2015-07-15
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier https://grdspublishing.org/index.php/life/article/view/7
 
Source LIFE: International Journal of Health and Life-Sciences; Vol 1 No 1 (2015): Regular Issue
2454-5872
 
Language eng
 
Relation https://grdspublishing.org/index.php/life/article/view/7/3386
 
Rights Copyright (c) 2017 Author(s)
 

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