The potential of carbonate apatite as an alternative bone substitute material

Medical Journal of Indonesia

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Field Value
 
Title The potential of carbonate apatite as an alternative bone substitute material
 
Creator Rahyussalim, Ahmad Jabir; Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
Supriadi, Sugeng; Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Depok
Marsetio, Aldo Fransiskus; Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
Pribadi, Pancar Muhammad; Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Depok
Suharno, Bambang; Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Depok
 
Subject bone graft; bone substitute; bone scaffold; calcium phosphate; carbonate apatite; orthopedic biomaterials
 
Description Bone reconstructive surgery has become a common procedure, and bone transplantation has become the second most frequently performed tissue transplantation procedure worldwide. Therefore, the need for bone substitute materials has increased. Artificial bone substitutes exhibit osteoconductive properties and feature several advantages, including abundant resources, low cost, and low donor site morbidity. Carbonate apatite (CO3Ap) is a calcium phosphate ceramic that can be used as a synthetic bone graft. The carbonate content of this ceramic is similar to that of bone apatite. In this review, we show that carbonate apatite can be degraded given its chemical reactivity in a weakly acidic environment and through osteoclast resorption. Moreover, it is osteoconductive and promotes bone tissue formation without fibrotic tissue formation. Additionally, microstructural analysis revealed that new bone tissue is formed within the bone graft itself.
 
Publisher Faculty of Medicine Universitas Indonesia
 
Contributor
 
Date 2019-05-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://mji.ui.ac.id/journal/index.php/mji/article/view/2681
10.13181/mji.v28i1.2681
 
Source Medical Journal of Indonesia; Vol 28, No 1 (2019): March; 92-7
2252-8083
0853-1773
10.13181/mji.v28i1
 
Language eng
 
Relation http://mji.ui.ac.id/journal/index.php/mji/article/view/2681/1316
 
Rights Copyright (c) 2019 Ahmad Jabir Rahyussalim, Sugeng Supriadi, Aldo Fransiskus Marsetio, Pancar Muhammad Pribadi
http://creativecommons.org/licenses/by-nc/4.0
 

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