Upregulation of FGFR3 and HIF-1α expression in muscle invasive bladder cancer

Medical Journal of Indonesia

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Field Value
 
Title Upregulation of FGFR3 and HIF-1α expression in muscle invasive bladder cancer
 
Creator Warli, Syah Mirsya; Department of Urology, Faculty of Medicine, Universitas Sumatera Utara, H. Adam Malik Hospital, Medan
Laksmi, Lidya Imelda; Department of Pathology, Faculty of Medicine, Universitas Sumatera Utara, H. Adam Malik Hospital, Medan
Safriadi, Ferry; Department of Urology, Faculty of Medicine, Universitas Padjajaran, Hasan Sadikin Hospital, Bandung
Umbas, Rainy; Department of Urology, Faculty of Medicine, Univesitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
 
Subject bladder cancer; fibroblast growth factor receptor-3; hypoxia-inducible factor-1α; predictive factors
 
Description BACKGROUND The major risks in patients diagnosed with non-muscle invasive bladder cancer (NMIBC)are recurrence, progression of muscle invasive bladder cancer (MIBC), and metastasis. Biological markers such as fibroblast growth factor receptor-3 (FGFR3) and hypoxia-inducible factor-1α (HIF-1α) are related to muscle invasiveness of bladder cancer. This study was aimed to analyze the expression of FGFR3 and HIF-1α to predict muscle invasiveness in bladder cancer patients.METHODS This was an observational study with a case-control design. Sixty patients with bladder cancer, who underwent histopathology examinations at the Department of Pathology, Faculty of Medicine, Universitas Sumatera Utara/H. Adam Malik Hospital from January 2012 to December 2015, were included in this study. Samples were then classified into 30 NMIBC and 30 MIBC groups. All samples were analyzed with an immunohistochemistry assay for FGFR3 and HIF-1α. H-scores were used to determine the relationships between each group.RESULTS FGFR3 was expressed in 29 (96.7%) patients of the NMIBC group, and 23 (76.7%) patients of the MIBC group (p=0.026, OR=8.8; 95% CI=1.01–76.96). HIF-1α was expressed in only 1 (3.33%) patient of the NMIBC group, and 15 (50%) patients of the MIBC group (p<0.001, OR=29; 95% CI=3.49–241.13).CONCLUSIONS There was a difference in upregulation of FGFR3 and HIF-1α expression in both the NMIBC and MIBC groups.
 
Publisher Faculty of Medicine Universitas Indonesia
 
Contributor Lidya Imelda Laksmi Univeristy of Sumatera Utara, Ferry Safriadi Padjajaran University, Rainy Umbas University of Indonesia
 
Date 2019-05-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://mji.ui.ac.id/journal/index.php/mji/article/view/2396
10.13181/mji.v28i1.2396
 
Source Medical Journal of Indonesia; Vol 28, No 1 (2019): March; 3-7
2252-8083
0853-1773
10.13181/mji.v28i1
 
Language eng
 
Relation http://mji.ui.ac.id/journal/index.php/mji/article/view/2396/1314
 
Rights Copyright (c) 2019 Syah Mirsya Warli, Lidya Imelda Laksmi, Ferry Safriadi, Rainy Umbas
http://creativecommons.org/licenses/by-nc/4.0
 

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