CD133, CD44, and ALDH1A1 as cancer stem cell markers and prognostic factors in epithelial ovarian cancer

Medical Journal of Indonesia

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Title CD133, CD44, and ALDH1A1 as cancer stem cell markers and prognostic factors in epithelial ovarian cancer
 
Creator Pelupessy, Nugraha Utama; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Hasanuddin, Makassar
Andrijono, Andrijono; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta
Sutrisna, Bambang; Department of Epidemiology, Faculty of Public Health, Universitas Indonesia, Jakarta
Harahap, Alida Roswita; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta
Kanoko, Mpu; Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta
Nuranna, Laila; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta
Siregar, Budiningsih; Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta
Wulandari, Dewi; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta
 
Subject aldehyde dehydrogenase 1A1; cancer stem cells; CD133 antigen; CD44 antigen; chemotherapy response; epithelial ovarian cancer
 
Description BACKGROUND Ovarian cancer is a heterogeneous disease, and most patients are diagnosed at an advanced stage. Epithelial ovarian cancer type II is characterized by rapid tumor growth and is genetically more labile than type I. This study was aimed to demonstrate the prognostic value of CSC by using the markers CD133, CD44, and ALDH1A1 in EOC.METHODS Clinicopathological and demographic data were collected from medical records. The markers CD133, CD44, and ALDH1A1 were examined with flow cytometry and immunohistochemistry. Cancer stem cell (CSC) marker expression in patients with ovarian cancer types I and II were related to chemotherapy and survival. In multivariate analysis, the prognosis model was tested for ten months.RESULTS The largest demographic consisted of patients aged ≥45 years, with stage I, poor differentiation, and type II, of which there were 40 samples (72.7%), 23 samples (41.8%), 30 samples (54.5%), and 16 samples (29.1%), respectively. There is a high correlation between the 10-month chemotherapy response and the 4 variables, i.e., age ≥45 years, type II, stage III–IV, and CD44, with an ROC of 80.75% and a post-test probability of 82.5%. Using the ROC curve, the highest chemoresistance score was 0.841, based on the combination of CSCs markers and clinicopathological factors, that is stage III–IV, age ≥45 years, poor differentiation, type II, negative CD133, high CD44, and high ALDH1A1.CONCLUSIONS CSC (CD133, CD44, and ALDH1A1) markers and clinicopathological factors are prognostic of epithelial ovarian cancer.
 
Publisher Faculty of Medicine Universitas Indonesia
 
Contributor Prof. Dr dr Andrijono, SpOGK, Prof. Dr dr Bambang Sutrisna, MHSc, dr Alida R Harahap, P. hd, SpPK(K), University of Indonesia, University of Hasanuddin.
 
Date 2019-05-08
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://mji.ui.ac.id/journal/index.php/mji/article/view/2863
10.13181/mji.v28i1.2863
 
Source Medical Journal of Indonesia; Vol 28, No 1 (2019): March; 63-9
2252-8083
0853-1773
10.13181/mji.v28i1
 
Language eng
 
Relation http://mji.ui.ac.id/journal/index.php/mji/article/view/2863/1320
 
Rights Copyright (c) 2019 Nugraha Utama Pelupessy, Andrijono Andrijono, Bambang Sutrisna, Alida R Harahap, Mpu Kanoko, Laila Nuranna, Budiningsih Siregar, Dewi Wulandari
http://creativecommons.org/licenses/by-nc/4.0
 

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