The Effect of Liberica Coffee on Liver Physiology and Histological Appearance of White Mice

Indonesian Journal of Cancer Chemoprevention

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Field Value
 
Title The Effect of Liberica Coffee on Liver Physiology and Histological Appearance of White Mice
 
Creator Kirana, Cindra Ayuning
Syamsurizal, Syamsurizal
Utami, Diah Tri
 
Description Indonesia is one of the world's top coffee producing and exporting countries. Liberica coffee was one of the most widely cultivated types of coffee in Indonesia, especially in Tanjung Jabung Barat Jambi Province. Liberica coffee known as the coffee with highest levels of caffeine if compared with Arabica and Robusta coffee but the research about Liberica coffee was still very little if compared to the other two types of coffee. In the previous research, caffeine shown to be increasing alanine aminotransferase enzyme. Otherwise, coffee also contain chlorogenic acid which is a potent antioxidant and play a role in the protection of liver. The aim of this study are to investigate the effect of dark roasted Liberica coffee consumption on liver histological appearance, macroscopic anatomy and physiological function (serum glutamic-pyruvic transaminase (SGPT) level). This was an experimental study with posttest only control group design, using 45 male white mice and divided into 4 groups: control (with no coffee treatment), P1, P2 and P3 which were given coffee treatment consecutively 8000 ppm; 10.000 ppm and 12.000 ppm for 28 days. The result showed that liver histological damage level associated with the extent coffee intake. Although, the damage shown is still in a low level and has no impact in increasing SGPT level.Keywords : Liberica coffee, Liver, Histological appearance, SGPT level
 
Publisher Indonesian Society for Cancer Chemoprevention
 
Contributor
 
Date 2018-10-30
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier https://ijcc.chemoprev.org/index.php/ijcc/article/view/247
10.14499/indonesianjcanchemoprev9iss3pp152-159
 
Source Indonesian Journal of Cancer Chemoprevention; Vol 9, No 3 (2018); 152-159
2355-8989
2088-0197
 
Language eng
 
Relation https://ijcc.chemoprev.org/index.php/ijcc/article/view/247/174
 
Rights Copyright (c) 2018 Cindra Ayuning Kirana
 

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