in vitro Antidiabetic, Antioxidant and Cytotoxic Activities of Syzygium cumini Fractions from Leaves Ethanol Extract

Indonesian Journal of Cancer Chemoprevention

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Field Value
 
Title in vitro Antidiabetic, Antioxidant and Cytotoxic Activities of Syzygium cumini Fractions from Leaves Ethanol Extract
 
Creator Artanti, Nina
Maryani, Faiza
Dewi, Rizna Triana
Handayani, Sri
Dewijanti, Indah Dwiatmi
Meilawati, Lia
Filaila, Euis
Udin, Linar Zalinar
 
Description Ethanol extract of Syzygium cumini (jamblang) leaves reveal its significant α-glucosidase inhibitory activity which perform the potential activity of this plant extract as antidiabetic agent. However, other bioactivities of this plant extract have been reported. The aim of current study was to evaluate the comparison of in vitro antidiabetic, antioxidant and cytotoxic activity of S. cumini fractions. The S. cumini leaves ethanol extract was fractionated by using column chromatography with n-hexane, ethyl acetate and methanol as eluents. Seven fractions were obtained from column chromatography (F1-7). The results showed that the best antidiabetic activity was found in F5 (93% α-glucosidase inhibitory activity), the best antioxidant activity was found in F4 (83% inhibition of DPPH free radical) and the best cytotoxic activity was found in F2 (69% growth inhibition of T47D breast cancer cell line). Therefore besides in vitro antidiabetic activity, fractions of S. cumini leaves ethanol extract also showed antioxidant and cytotoxic activities. Since the results showed that the most active fractions for antidiabetic, antioxidant and cytotoxicity were differed, it could be possible to isolate the different potential active compounds for each activity.Keywords : Syzygium cumini, α-glucosidase inhibitor, DPPH, cytotoxicity
 
Publisher Indonesian Society for Cancer Chemoprevention
 
Contributor
 
Date 2019-02-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier https://ijcc.chemoprev.org/index.php/ijcc/article/view/262
10.14499/indonesianjcanchemoprev10iss1pp24-29
 
Source Indonesian Journal of Cancer Chemoprevention; Vol 10, No 1 (2019); 24-29
2355-8989
2088-0197
 
Language eng
 
Relation https://ijcc.chemoprev.org/index.php/ijcc/article/view/262/178
 
Rights Copyright (c) 2019 Nina Artanti, Linar Zalinar Udin, Faiza Maryani, Rizna Triana Dewi, Sri Handayani, Indah Dwiatmi Dewijanti, Lia Meilawati, Euis Filaila
 

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