IMPLICATION OF FIVE AIDS RELATED GENES IN MOTHER-TO-CHILD TRANSMISSION AND ACQUISITION OF HUMAN IMMUNODEFICIENCY VIRUS 1 IN CAMEROON

African Journal of Infectious Diseases (AJID)

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Title IMPLICATION OF FIVE AIDS RELATED GENES IN MOTHER-TO-CHILD TRANSMISSION AND ACQUISITION OF HUMAN IMMUNODEFICIENCY VIRUS 1 IN CAMEROON
 
Creator Mekue, Linda Mouafo
Nkenfou, Céline Nguefeu
Dambaya, Beatrice
Fotso, Idriss
Nguefack, Felicitée
Fainguem, Nadine
Lobè, Elise Elong
Kuiaté, Jules Roger
Ndjolo, Alexis
 
Subject HIV
Host genetic factors
Mother-to-child-transmission
Cameroon
 
Description Background: Genetic variants in the mother and/or infant have been described with evidence to be associated with
mother-to-child transmission of HIV, but somehow with contradictory results depending on ethnic or geographic
populations. We aimed at looking at the association between the allelic frequency of some genes with vertical
transmission or acquisition of HIV in Cameroon.
Methodology: A total of 262 mothers (212 HIV-infected and 50 HIV non-infected) with their babies (270 in total, 42
HIV exposed-infected, 178 HIV exposed non-infected and 50 HIV non-exposed) were recruited in Yaounde-
Cameroon. Their genotypes for CCR5-Delta32, CCR5 promoter59029A/G, CCR2-64I, SDF1-3’A andTRIM5α-136Q
were analyzed using polymerase chain reaction and restriction fragment length polymorphisms.
Results: Allelic frequencies were 14.7%, 41.9%, 9.5% and 14.7% for CCR2-64I, CCR5-59029-A/G, TRIM5α-136Q,
SDF1-3’A respectively in the mothers and 18.8%, 35.9%, 11.3% and 20.5% in the babies. No delta 32 mutation in the
CCR5 gene was found. The mutant genotype was most significantly frequent in the non-transmitter than in the
transmitter (p= 0.005) for the SDF-1 3'A. SDF1-3’A [Odd ratio = 1.69; 95% confidence interval: 0.1158 to 0.7277);
was associated to MTCT, P = 0.008.The homozygote mutants for the CCR5-59029-G were significantly higher in the
infected than in the exposed uninfected babies (p=0.04). The mutations in the other genes were neither implicated in the
acquisition nor in the transmission.
Conclusion: SDF1-3’A was associated to the reduction of MTCT. The CCR5-59029-A/G favored acquisition of HIV
by babies. Our study showed that polymorphisms in chemokine ligand may be involved in MTCT.
 
Publisher African Traditional Medicine Supporters Initiative (ATHMSI), 7, Road 1, Otunmaiye Square
 
Date 2018-12-12
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier http://journals.athmsi.org/index.php/AJID/article/view/5220
 
Source African Journal of Infectious Diseases (AJID); Vol 13 No 1 (2019); 1-10
2505-0419
2006-0165
 
Language eng
 
Relation http://journals.athmsi.org/index.php/AJID/article/view/5220/3163
 
Rights Copyright (c) 2018 Linda Mouafo Mekue, Céline Nguefeu Nkenfou, Beatrice Dambaya, Idriss Fotso, Felicitée Nguefack, Nadine Fainguem, Elise Elong Lobè, Jules Roger Kuiaté, Alexis Ndjolo
http://creativecommons.org/licenses/by/4.0
 

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